Obesity Linked to Increased Risk of Heart Failure
Observational and Mendelian Randomization Analyses Reveal Correlation
Key Findings
Evidence from both observational and Mendelian randomization analyses in 30 million people indicates that obesity is a significant risk factor for heart disease, ultimately leading to heart failure (HF).
Individuals with obesity face an elevated risk of developing HF, which is associated with an increased likelihood of cardiovascular events such as stroke and myocardial infarction.
Studies have highlighted the role of adipocytokines and their pro-inflammatory cytokines in the pathophysiology of HF, contributing to the development and progression of the condition.
Obesity directly influences incident cardiovascular risk factors, including dyslipidemia and type 2 diabetes, further increasing the risk of HF.
This summary outlines the impact of obesity on the diagnosis, clinical management, and prognosis of HF, highlighting the importance of weight management and lifestyle modifications to reduce the associated risks.
A recent small study led by Johns Hopkins Medicine researchers, published in the journal "Circulation," found that higher body mass index (BMI) and waist-to-hip ratio, indicators of obesity, were associated with a greater likelihood of HF.
Comments